Institut des Sciences Moléculaires d'Orsay



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Accueil > Séminaires > Année 2018 > Séminaire de Emilio J. Cocinero (2 octobre 2018)

Séminaire de Emilio J. Cocinero (2 octobre 2018)

Universidad del País Vasco (UPV/EHU) and Fundación Biofisika Bizkaia (CSIC-UPV/EHU)

par Martrenchard-Barra Séverine - 18 septembre 2018

I present several studies on biomolecules (carbohydrates and glycopeptides) and several applications, exploiting an experimental strategy which combines microwave and laser spectroscopies in high resolution, computation and synthesis. Laser spectroscopy offers high sensitivity and selectivity, making it ideal for studying biochemical systems of medium-large size.[1-2] Moreover, microwave spectroscopy provides higher resolution and direct access to molecular structure. This combined approach provides not only accurate chemical insight on conformation, structure and molecular properties, but also benchmarking standards guiding the development of theoretical calculations. In order to illustrate these possibilities, we present the results on the conformational landscape of several carbohydrates,cpeptides and glycopeptides[2] with different biological roles. In addition, others applications of high resolution spectroscopies are presented.[6]

[1] E. J. Cocinero, P. Çarcabal, T. D. Vaden, J. P. Simons, B. G. Davis, Nature 2011, 469, 76.
[2] I. A. Bermejo, I. Usabiaga, I. Compañón, J. Castro-López, A. Insausti, J. A. Fernández, A. Avenoza, J. H. Busto, J. Jiménez-Barbero, J. L. Asensio, J. M. Peregrina, G. Jiménez-Osés, R. Hurtado-Guerrero, E. J. Cocinero and F. Corzana J. Am. Chem. Soc., 2018, 140, 9952.
[3] E. J. Cocinero, A. Lesarri, P. Écija, F. J. Basterretxea, J.-U. Grabow, J. A. Fernández, F. Castaño, Angew. Chem. Int. Ed., 2012, 51, 3119.
[4] E. J. Cocinero, A. Lesarri, P. Écija, Á. Cimas, B. G. Davis, F. J. Basterretxea, J. A. Fernández, F. Castaño, J. Am. Chem. Soc., 2013, 135, 2845.
[5] P. Écija, I. Uriarte, L. Spada, B. G. Davis, W. Caminati, F. J. Basterretxea, A. Lesarri, E. J. Cocinero, Chem. Comm., 2016, 52, 6241.
[6] M. Carini, M. P. Ruiz, I.Usabiaga, J. A. Fernández, E. J. Cocinero, M. Melle-Franco, I. Diez-Pérez and A. Mateo-Alonso Nat. Comm., 2017, 8, 15195.

Séminaire d’Emilio Cocinero - 139.4 kio

2 oct. 2018