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Accueil > Séminaires > Année 2023 > Séminaire de Philippe-Henri Secrétan et Bernard Do (15 nov)

Séminaire de Philippe-Henri Secrétan et Bernard Do (15 nov)

UFR de Pharmacie, Université Paris-Saclay

par Martrenchard-Barra Séverine - 28 octobre 2023 (modifié le 2 novembre 2023)

In vitro chemical stability profile and ex vivo fate of a new topically applied drug studied by mass spectrometry

Understanding the intrinsic stability profile, especially with respect to light exposure, and the ex vivo fate of new active substances intended for topical or local use is vital in designing stable and efficient new drugs.
On the one hand, light exposure is a crucial factor to assess, as the skin is routinely exposed to light, making it essential to understand how it affects the chemical stability of the drug. On the other hand, ex vivo fate, encompassing factors like permeation, metabolism, and potential degradation within the skin, directly influences the drug’s therapeutic performance.
During this seminar, we will provide some examples of studies where mass spectrometry has served as an invaluable tool for getting access to this critical information. It not only helped us to identify chemical changes, degradation products, and metabolites but also allowed us to track the drug’s skin permeation and potential alterations in the various skin layers. These comprehensive data have contributed to the design of new drugs that are both stable and highly efficient, ensuring the best possible patient outcomes.

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